In this area our teams are elucidating the biochemical and cellular basis of human diseases and the molecular mechanisms underlying drug action and their targets.
Our investigation of disease mechanisms provides insights into identification of novel therapeutic targets for which small molecules or biologics are being developed. Research is directed towards the molecular and cellular mechanisms underlying the function of therapeutic targets, correcting the target using gene therapy, and the intracellular signalling pathways they control and the mechanistic study of drug action. Approaches incorporate human studies, patient-derived samples and animal models of disease. Our research teams are interested in several human diseases or conditions including drug addiction, autism, diabetes, cancer, genetic disorders, infectious diseases, and neurological diseases.
Investigators
Research News
Focused ultrasound enhanced delivery of targeted antibody therapy to breast cancer that spread to the brain
Radiopharmaceutical drug developed at Leslie Dan Faculty of Pharmacy helps realize “breakthrough moment” enabling clinical researchers to determine if treatment can target brain metastases.
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New research grants support research to improve COVID-19 vaccination efforts
Two assistant professors at U of T’s Leslie Dan Faculty of Pharmacy have been awarded new funding to examine different COVID-19 vaccine delivery efforts.
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Expert in pandemic ethics helps shape public conversations
Alison Thompson’s media expert and provincial advisory roles contribute to public discussions about challenging topics during COVID-19 pandemic.
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