Faces of PharmSci: Alessia Pileggi

What is your academic background and why is this area of research important?

I graduated with an Honours Bachelor of Science in Biology from Toronto Metropolitan University (TMU) last June. During my time at TMU, I had the opportunity to conduct research across several different fields, which confirmed my strong interest in scientific inquiry. In my fourth year, I completed an undergraduate thesis in a microbiology lab where I investigated the effectiveness of a novel disinfectant against chlorine-resistant bacteria in drinking water distribution systems. This area of research is very important as microbial contamination in water systems poses significant public health risks and the emergence of resistant bacteria highlights the need for improved treatment strategies.

My background in microbiology has also provided me with valuable technical skills, including aseptic technique, which is essential for following Good Manufacturing Practices (GMP) and ensuring the safe preparation of drugs such as radiopharmaceuticals for first-in-human clinical trials. Additionally, as I have learned more about cancer through my current research, I have come to appreciate the surprising similarities between bacterial and cancer cells; both are highly adaptive, rapidly proliferating systems that develop resistance mechanisms we aim to overcome. Across both of my research experiences, a common theme has been addressing resistance—whether through utilizing a novel disinfectant or developing a targeted radiopharmaceutical—with the shared goal of eliminating harmful cells and improving human health.

What led you to your current Supervisor’s lab/research group?

What led me to my current supervisor’s lab was a strong interest in targeted cancer therapies and the interdisciplinary nature of the work. I had previously been familiar with external beam radiation therapy in cancer treatment, but radiopharmaceuticals were a completely new and fascinating area for me. I was particularly drawn to how radioactive forms of chemical elements, or radioisotopes, can be used for both diagnosing and treating cancer in a highly targeted and customizable way.

I also appreciated how Dr. Reilly’s lab brought together concepts from biology, chemistry, and physics in a way that felt both innovative and highly impactful. I found it especially exciting that this field allows me to continue applying my biology background while also learning more about receptor biology and the tumour microenvironment. Overall, the combination of scientific disciplines and the focus on precision cancer therapy made this lab a perfect fit for my interests.

What are some of the challenges you had to overcome within your research?

Since targeted radionuclide therapy and the broader field of nuclear medicine were new to me, I had to quickly adapt to a completely different research environment. To become a Nuclear Energy Worker, I completed rigorous radiation safety training and familiarized myself with strict protocols, monitoring procedures, and radiation dose concepts, all of which I found highly interesting and valuable. I also had to master field-specific experimental techniques, such as radio-instant thin layer chromatography, which is used to assess the purity of radiopharmaceuticals. Although this area was initially unfamiliar, I was able to adapt quickly with the support and mentorship within the Reilly lab, for which I am very grateful.

How do you see your current research playing a role in your career?

I am interested in contributing to the development of new therapies and ultimately pursuing a career as a professor, where I can combine teaching with clinical research. My long-term goal is to help improve cancer treatment strategies and patient outcomes by advancing the field of cancer therapy. I am particularly motivated by the opportunity to translate scientific discoveries into meaningful clinical impact and to contribute to improving patient prognoses.

What do you like to do when you are not working on research?

I enjoy exploring Toronto’s diverse food scene, especially trying different Asian cuisines—the city’s multicultural environment makes this one of my favourite parts of living here. In my free time, I also like to stay active through biking and going to the gym, which I find to be a great mental break. I also treat my kitchen like a lab, experimenting with baking healthier, protein-rich recipes and seeing if I can create something that is both nutritious and actually tastes good!

Outside of this, I’m passionate about learning new languages and I often use Duolingo to support this interest. I also enjoy creative writing and like to spend time writing fiction stories when I can.